Nonblinking and Nonbleaching Upconverting Nanoparticles as an Optical Imaging Nanoprobe and T1 Magnetic Resonance Imaging Contrast Agent (pages 4467–4471)
Yong Il Park, Jeong Hyun Kim, Kang Taek Lee, Ki-Seok Jeon, Hyon Bin Na, Jung Ho Yu, Hyung Min Kim, Nohyun Lee, Seung Hong Choi, Sung-Il Baik, Hyoungsu Kim, Seung Pyo Park, Beom-Jin Park, Young Woon Kim, Sung Ho Lee, Soo-Young Yoon, In Chan Song, Woo Kyung Moon, Yung Doug Suh and Taeghwan Hyeon
Version of Record online: 29 JUN 2009 | DOI: 10.1002/adma.200901356
Core/shell upconverting nanoparticles (UCNPs) of NaGdF4:Er3+,Yb3+/NaGdF4 (see figure) are shown to serve as a multimodal imaging probe that works for both background-free optical imaging and magnetic resonance imaging (MRI). The nonblinking and nonbleaching properties of UCNPs can contribute to minimization of possible artifacts in long-term imaging experiments. Owing to Gd3+ ions in the host matrix, contrast is enhanced in T1-weighted MRI.