Non-invasive Transdermal Delivery Route Using Electrostatically Interactive Biocompatible Nanocapsules (pages 739–743)
Jinseob Shin, Kyomin Shin, Hanna Lee, Jeong-Beom Nam, Jae-Eun Jung, Jee-Hyun Ryu, Joo-Hyun Han, Kyung-Do Suh, Yong-Jin Kim, Jongwon Shim, Junoh Kim, Sang-Hoon Han, Kookheon Char, Yeon Kyung Kim, Jin Ho Chung, Min Jung Lee, Byeong Cheol Kang and Jin-Woong Kim
Article first published online: 25 NOV 2009 | DOI: 10.1002/adma.200902079
A robust means of fabricating skin-penetrating and compatible nanocarriers comprising poly(D, L-lactide-co-glycolide) is reported. The resultant nanocapsules have the ability to load biologically active ingredients and selectively release them through the epidermis lipid layer. Their release of genistein (left figure) is determined to be diffusion-controlled, and they are shown to successfully deliver molecules, such as nile red (right figure), into biopsied skin samples.