Cooperation of Biological and Mechanical Signals in Cardiac Progenitor Cell Differentiation (pages 514–518)
Stefania Pagliari, Ana Cristina Vilela-Silva, Giancarlo Forte, Francesca Pagliari, Corrado Mandoli, Giovanni Vozzi, Stefano Pietronave, Maria Prat, Silvia Licoccia, Arti Ahluwalia, Enrico Traversa, Marilena Minieri and Paolo Di Nardo
Version of Record online: 12 NOV 2010 | DOI: 10.1002/adma.201003479
Three-dimensional cardiac tissue-specific scaffolds made of poly-lactic acid (PLA) have an ordered array of square pores reproducing anisotropic cardiac-like stiffness. The mechano-physical features of the scaffolds favor cardiomyocyte adhesion and survival and combined with biological signals released by neonatal cardiomyocytes can accelerate cardiac stem cell differentiation by emulating in vitro cardiac niche.