Functional Inclusion Bodies Produced in Bacteria as Naturally Occurring Nanopills for Advanced Cell Therapies (pages 1742–1747)
Esther Vázquez, José L. Corchero, Joan F. Burgueño, Joaquin Seras-Franzoso, Ana Kosoy, Ramon Bosser, Rosa Mendoza, Joan Marc Martínez-Láinez, Ursula Rinas, Ester Fernández, Luis Ruiz-Avila, Elena García-Fruitós and Antonio Villaverde
Article first published online: 13 MAR 2012 | DOI: 10.1002/adma.201104330
Inclusion bodies (50–500 nm in diameter) produced in recombinant bacteria can be engineered to contain functional proteins with therapeutic potential. Upon exposure, these protein particles are efficiently internalized by mammalian cells and promote recovery from diverse stresses. Being fully biocompatible, inclusion bodies are a novel platform, as tailored nanopills, for sustained drug release in advanced cell therapies.