Theranostic Probe Based on Lanthanide-Doped Nanoparticles for Simultaneous In Vivo Dual-Modal Imaging and Photodynamic Therapy (pages 5755–5761)
Yong Il Park, Hyung Min Kim, Jeong Hyun Kim, Kyung Chul Moon, Byeongjun Yoo, Kang Taek Lee, Nohyun Lee, Yoonseok Choi, Wooram Park, Daishun Ling, Kun Na, Woo Kyung Moon, Seung Hong Choi, Hong Seok Park, Soo-Young Yoon, Yung Doug Suh, Sung Ho Lee and Taeghwan Hyeon
Article first published online: 23 AUG 2012 | DOI: 10.1002/adma.201202433
Dual-modal in vivo tumor imaging and photodynamic therapy using hexagonal NaYF4:Yb,Er/NaGdF4 core–shell upconverting nanoparticles combined with a photosensitizer, chlorin e6, is reported. Tumors can be clearly observed not only in the upconversion luminescence image but also in the magnetic resonance image. In vivo photodynamic therapy by systemic administration is demonstrated under 980 nm irradiation.