Modular ‘Click-in-Emulsion’ Bone-Targeted Nanogels (pages 1449–1454)
Daniel A. Heller, Yair Levi, Jeisa M. Pelet, Joshua C. Doloff, Jasmine Wallas, George W. Pratt, Shan Jiang, Gaurav Sahay, Avi Schroeder, Josh E. Schroeder, Yieu Chyan, Christopher Zurenko, William Querbes, Miguel Manzano, Daniel S. Kohane, Robert Langer and Daniel G. Anderson
Article first published online: 27 DEC 2012 | DOI: 10.1002/adma.201202881
A new class of nanogel demonstrates modular biodistribution and affinity for bone. Nanogels, ∼70 nm in diameter and synthesized via an astoichiometric click-chemistry in-emulsion method, controllably display residual, free clickable functional groups. Functionalization with a bisphosphonate ligand results in significant binding to bone on the inner walls of marrow cavities, liver avoidance, and anti-osteoporotic effects.