High-Purity Prostate Circulating Tumor Cell Isolation by a Polymer Nanofiber-Embedded Microchip for Whole Exome Sequencing (pages 2897–2902)
Libo Zhao, Yi-Tsung Lu, Fuqiang Li, Kui Wu, Shuang Hou, Juehua Yu, Qinglin Shen, Dongxia Wu, Min Song, Wei-Han OuYang, Zheng Luo, Tom Lee, Xiaohong Fang, Chen Shao, Xun Xu, Mitch A. Garcia, Leland W. K. Chung, Matthew Rettig, Hsian-Rong Tseng and Edwin M. Posadas
Version of Record online: 26 MAR 2013 | DOI: 10.1002/adma.201205237
Handpick single cancer cells: A modified NanoVelcro Chip is coupled with ArcturusXT laser capture microdissection (LCM) technology to enable the detection and isolation of single circulating tumor cells (CTCs) from patients with prostate cancer (PC). This new approach paves the way for conducting next-generation sequencing (NGS) on single CTCs.