Cell-laden Microengineered and Mechanically Tunable Hybrid Hydrogels of Gelatin and Graphene Oxide (pages 6385–6391)
Su Ryon Shin, Behnaz Aghaei-Ghareh-Bolagh, Tram T. Dang, Seda Nur Topkaya, Xiguang Gao, Seung Yun Yang, Sung Mi Jung, Jong Hyun Oh, Mehmet R. Dokmeci, Xiaowu (Shirley) Tang and Ali Khademhosseini
Version of Record online: 1 SEP 2013 | DOI: 10.1002/adma.201301082
Incorporating graphene oxide inside GelMA hydrogels enhances their mechanical properties and reduces UV-induced cell damage while preserving their favorable characteristics for 3D cell encapsulation. NIH-3T3 fibroblasts encapsulated in GO-GelMA microgels demonstrate excellent cellular viability, proliferation, spreading, and alignment. GO reinforcement combined with a multi-stacking approach offers a facile engineering strategy for the construction of complex artificial tissues.