Highly Fluorescent Dye-Aggregate-Enhanced Energy-Transfer Nanoparticles for Neuronal Cell Imaging

Authors

  • Xinyang Li,

    1. CAS Key Laboratory of Soft Matter Chemistry, Department of Polymer Science and Engineering, University of Science and Technology of China, Hefei, China
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  • Huijing Liu,

    1. CAS Key Laboratory of Brain Function and Disease and Department of Neurobiology and Biophysics, School of Life Sciences, University of Science and Technology of China, Hefei, China
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  • Xingxing Sun,

    1. CAS Key Laboratory of Soft Matter Chemistry, Department of Polymer Science and Engineering, University of Science and Technology of China, Hefei, China
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  • Guoqiang Bi,

    Corresponding author
    • CAS Key Laboratory of Brain Function and Disease and Department of Neurobiology and Biophysics, School of Life Sciences, University of Science and Technology of China, Hefei, China
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  • Guoqing Zhang

    Corresponding author
    • CAS Key Laboratory of Soft Matter Chemistry, Department of Polymer Science and Engineering, University of Science and Technology of China, Hefei, China
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E-mail: gzhang@ustc.edu.cn, gqbi@ustc.edu.cn

Abstract

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Dye aggregates give energy transfer a boost! Efficient energy transfer between organoboron and Rhodamine dyes are utilized to produce two-photon excitable polylactide nanoparticles, which exhibit high brightness and photostability. These ‘super-bright’ nanoparticles are particularly suited for imaging sensitive specimens such as live neuronal cells. Tissue imaging is also demonstrated, to show that such new imaging agents can find various applications for life sciences.

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