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Label-Free Biosensor Based on an All-Polymer DFB Laser

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Abstract

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A monolithic active optical resonator biosensor is fabricated for label-free sensing. The all-polymer sensor consists of a polymer distributed feedback (DFB) laser and a hydrogel recognition layer. Specific binding of analyte modulates the effective refractive index, shifting the laser emission wavelength. Real time detection of avidin–biotin interactions is demonstrated as a model for the new label-free biosensing principle.

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