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Keywords:

  • C[BOND]C coupling reactions;
  • C[BOND]N coupling reactions;
  • industrial research;
  • Ni catalysis;
  • Pd catalysis

Abstract

R&D issues for the application of Pd- and Ni-catalyzed C[BOND]C and C[BOND]N coupling reactions in the fine chemicals industry are discussed. In a first part, some background is given on industrial R&D and the role of C[BOND]C and C[BOND]N coupling for preparative applications is described. The following principal approaches to industrial research are illustrated with relevant examples from the literature and from our own laboratories: i) development of catalysts and catalytic methodologies with industrial potential; ii) finding shorter routes to target molecules using catalytic methods; iii) development of industrial catalytic processes in multi-step syntheses.