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Keywords:

  • allylic substitution;
  • chelation-induced;
  • copper;
  • Heck reaction;
  • palladium;
  • pyridyl sulfone

Abstract

The development of a chelation-assisted, transition metal-catalyzed protocol for the sequential multiarylation of cyclic allyl sulfones is described. The metal-coordinating ability of the 2-pyridyl group on the sulfone promotes the otherwise difficult intermolecular Heck monoarylation and diarylation of trisubstituted alkenes, as well as the copper-catalyzed allylic arylation with Grignard reagents.