A Practical and Chemoselective Reduction of Nitroarenes to Anilines Using Activated Iron

Authors

  • Yugang Liu,

    1. Process Research and Development, Department of Chemical and Analytical Development, Novartis Institute for Biomedical Research, One Health Plaza, East Hanover, New Jersey 07936, USA, Fax: (+1)-973-781-2188
    Search for more papers by this author
  • Yansong Lu,

    1. Process Research and Development, Department of Chemical and Analytical Development, Novartis Institute for Biomedical Research, One Health Plaza, East Hanover, New Jersey 07936, USA, Fax: (+1)-973-781-2188
    Search for more papers by this author
  • Mahavir Prashad,

    1. Process Research and Development, Department of Chemical and Analytical Development, Novartis Institute for Biomedical Research, One Health Plaza, East Hanover, New Jersey 07936, USA, Fax: (+1)-973-781-2188
    Search for more papers by this author
  • Oljan Repič,

    1. Process Research and Development, Department of Chemical and Analytical Development, Novartis Institute for Biomedical Research, One Health Plaza, East Hanover, New Jersey 07936, USA, Fax: (+1)-973-781-2188
    Search for more papers by this author
  • Thomas J. Blacklock

    1. Process Research and Development, Department of Chemical and Analytical Development, Novartis Institute for Biomedical Research, One Health Plaza, East Hanover, New Jersey 07936, USA, Fax: (+1)-973-781-2188
    Search for more papers by this author

Abstract

Reduction of nitroarenes to anilines using activated iron generated by Fe/HCl or Zn/FeSO4 is described. A variety of functional groups such as alkyne, ketone, enone, nitrile, lactone, and aromatic halide are well tolerated under these conditions.

Ancillary