Transition Metal-Catalyzed Asymmetric Hydroamination of Alkenes (AHA)



The hydroamination of unsaturated carbon-carbon linkages allows a facile and highly atom-economical access to industrially relevant nitrogen-containing basic and fine chemicals as well as naturally occurring alkaloid skeletons. Significant research efforts have led to the development of efficient catalyst systems for intra- and intermolecular hydroamination reactions. Of particular interest are hydroaminations promoted by chiral catalysts, in which a new chiral center is generated or chiral substrates are kinetically resolved. This review will give an overview on the current state of the art in this rapidly evolving field of catalysis.