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Keywords:

  • asymmetric catalysis;
  • asymmetric synthesis;
  • C[BOND]C coupling;
  • chiral auxiliaries;
  • quaternary stereocenters;
  • synthetic methods

Abstract

Quaternary stereocenters are a particular challenge for stereoselective synthesis. With a central view on this specific structural issue, selected examples from the recent literature are highlighted in order to evaluate the state of the art of asymmetric C[BOND]C bond formation. The review is divided into sections on addition and substitution reactions, rearrangements and cycloaddition reactions.