Full Paper

PuPHOS and CamPHOS Ligands in the Intermolecular Catalytic Pauson–Khand Reaction

  1. Agustí Lledó1,
  2. Jordi Solà1,
  3. Xavier Verdaguer1,
  4. Antoni Riera1,
  5. Miguel A. Maestro2

Article first published online: 11 SEP 2007

DOI: 10.1002/adsc.200700145

Issue

Advanced Synthesis & Catalysis

Advanced Synthesis & Catalysis

Volume 349, Issue 13, pages 2121–2128, September 3, 2007

Additional Information

How to Cite

Lledó, A., Solà, J., Verdaguer, X., Riera, A. and Maestro, Miguel A. (2007), PuPHOS and CamPHOS Ligands in the Intermolecular Catalytic Pauson–Khand Reaction. Adv. Synth. Catal., 349: 2121–2128. doi: 10.1002/adsc.200700145

Author Information

  1. 1

    Unitat de Recerca en Síntesi Asimètrica (URSA-PCB), Institute for Research in Biomedicine (IRB Barcelona) and Departament de Química Orgànica, Universitat de Barcelona, c/Josep Samitier 1–5, 08028 Barcelona, Spain, Fax: (+34)-9-3403-7095

  2. 2

    Departamento de Química Fundamental, Universidade da Coruña, 15071 A Coruña, Spain

Publication History

  1. Issue published online: 18 SEP 2007
  2. Article first published online: 11 SEP 2007
  3. Manuscript Received: 21 MAR 2007

SEARCH

SEARCH BY CITATION

ARTICLE TOOLS

Get PDF (269K)

Keywords:

  • asymmetric catalysis;
  • cobalt;
  • hydrogen bonds;
  • P,S ligands;
  • Pauson–Khand reaction

Abstract

The first asymmetric intermolecular cobalt-catalyzed Pauson–Khand reaction is described. The use of the hemilabile CamPHOS ligand provides good conversions and selectivity up to 28 % ee. The catalytic process was studied by in situ FT-IR and it was found that both bridged and non-bridged complexes were present in the reaction mixture. Our results suggest that recognition between the alkyne substrate and the ligand is essential to attain stereocontrol in the catalytic cyclization.

Get PDF (269K)