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Full Paper
Chiral Thiourea-Phosphine Organocatalysts in the Asymmetric Aza-Morita–Baylis–Hillman Reaction
Article first published online: 11 SEP 2007
DOI: 10.1002/adsc.200700155
Copyright © 2007 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Additional Information
How to Cite
Shi, Y.-L. and Shi, M. (2007), Chiral Thiourea-Phosphine Organocatalysts in the Asymmetric Aza-Morita–Baylis–Hillman Reaction. Adv. Synth. Catal., 349: 2129–2135. doi: 10.1002/adsc.200700155
Publication History
- Issue published online: 18 SEP 2007
- Article first published online: 11 SEP 2007
- Manuscript Received: 25 MAR 2007
Keywords:
- asymmetric catalysis;
- Morita–Baylis–Hillman reaction;
- NMR spectroscopy;
- organic catalysis;
- thiourea-phosphine organocatalysts
Abstract
A new kind of bifunctional (thio)urea-phosphine catalyst was synthesized and applied to the aza-Morita–Baylis–Hillman reaction of N-sulfonated imines with methyl vinyl ketone, phenyl vinyl ketone, ethyl vinyl ketone or acrolein. Moderate to excellent ee and yields of the products were obtained under mild reaction conditions.