Communication

Efficient Synthesis of a Novel Resorcyclide as Anticancer Agent Based on Hsp90 Inhibition

  1. Xiaoguang Lei1,
  2. Samuel J. Danishefsky1,2

Article first published online: 20 JUN 2008

DOI: 10.1002/adsc.200800187

Issue

Advanced Synthesis & Catalysis

Advanced Synthesis & Catalysis

Volume 350, Issue 11-12, pages 1677–1681, August 4, 2008

Additional Information

How to Cite

Lei, X. and Danishefsky, Samuel J. (2008), Efficient Synthesis of a Novel Resorcyclide as Anticancer Agent Based on Hsp90 Inhibition. Adv. Synth. Catal., 350: 1677–1681. doi: 10.1002/adsc.200800187

Author Information

  1. 1

    Department of Chemistry, Columbia University, Havemeyer Hall, 3000 Broadway, New York, New York 10027, USA

  2. 2

    Laboratory for Bioorganic Chemistry, Sloan-Kettering Institute for Cancer Research, 1275 York Avenue, New York, New York 10065, USA, Fax: (+1)-212-772-8691; phone: (+1)-212-639-5502

Publication History

  1. Issue published online: 31 JUL 2008
  2. Article first published online: 20 JUN 2008
  3. Manuscript Received: 28 MAR 2008

Funded by

  • National Institutes of Health. Grant Number: CA28824
  • NSF. Grant Number: CHE-0619638

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Keywords:

  • antitumor agents;
  • click chemistry;
  • heat shock protein 90;
  • total synthesis;
  • triazole-cycloproparadicicol

Abstract

The highly efficient synthesis of a novel heat shock protein 90 (Hsp90)-based anticancer agent, triazole-cycloproparadicicol (5), is described. The key step involves a fragment coupling using “click chemistry.” The preliminary biological evaluation of triazole-cycloproparadicicol is also reported.

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