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Full Paper
Catalytic Deprotonative Functionalization of Propargyl Silyl Ethers with Imines
Article first published online: 31 JUL 2008
DOI: 10.1002/adsc.200800281
Copyright © 2008 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Additional Information
How to Cite
Naka, H., Koseki, D. and Kondo, Y. (2008), Catalytic Deprotonative Functionalization of Propargyl Silyl Ethers with Imines. Adv. Synth. Catal., 350: 1901–1906. doi: 10.1002/adsc.200800281
Publication History
- Issue published online: 31 JUL 2008
- Article first published online: 31 JUL 2008
- Manuscript Revised: 9 JUN 2008
- Manuscript Received: 7 MAY 2008
Funded by
- Grants-in-Aid for Scientific Research on Priority Areas
- Grants-in-Aid for Young Scientists (B)
- IREMC
Keywords:
- anionic reactions;
- C
![[BOND]](http://onlinelibrarystatic.wiley.com/undisplayable_characters/00f8ff.gif)
C bond formation; - heterocycles;
- metal-free conditions;
- phosphazene bases
Abstract
A metal-free, catalytic CH functionalization of propargyl silyl ethers with imines using the phosphazene base (t-Bu-P4 base) provides structurally defined multisubstituted pyrroles in modest to excellent yields under mild conditions. A one-pot, three-component reaction using silylated acetylenes, aldehydes, and imines is also presented.