SEARCH

SEARCH BY CITATION

Keywords:

  • aza-Henry reaction;
  • guanidines;
  • organic catalysts;
  • phase-transfer catalyst;
  • thioureas

Abstract

Thumbnail image of graphical abstract

A highly enantioselective aza-Henry reaction of imines with nitromethane was achieved with a reactive guanidine-thiourea bifunctional organocatalyst affording β-nitroamines with high enantioselectivity (up to 96% ee). The diastereo- and enantioselective version of this reaction with nitroalkanes also proceeded selectively (up to 99:1 dr with 99% ee).