Communication

The Use of Copper Flow Reactor Technology for the Continuous Synthesis of 1,4-Disubstituted 1,2,3-Triazoles

  1. Andrew R. Bogdan1,
  2. Neal W. Sach2

Article first published online: 6 APR 2009

DOI: 10.1002/adsc.200800758

Issue

Advanced Synthesis & Catalysis

Advanced Synthesis & Catalysis

Volume 351, Issue 6, pages 849–854, April 2009

Additional Information

How to Cite

Bogdan, A. and Sach, N. (2009), The Use of Copper Flow Reactor Technology for the Continuous Synthesis of 1,4-Disubstituted 1,2,3-Triazoles. Advanced Synthesis & Catalysis, 351: 849–854. doi: 10.1002/adsc.200800758

Author Information

  1. 1

    Cornell University, Department of Chemistry and Chemical Biology, Ithaca, NY 14853, USA

  2. 2

    Pfizer Inc., Global Research and Development, Medicinal Chemistry, 10777 Science Centre Drive, San Diego, CA 92121, USA, Fax: (+1)-858-678-8244; phone: (+1)-858-622-7938

Publication History

  1. Issue published online: 15 APR 2009
  2. Article first published online: 6 APR 2009
  3. Manuscript Revised: 12 MAR 2009
  4. Manuscript Received: 8 DEC 2008

Funded by

  • Pfizer Student Employment Program

SEARCH

SEARCH BY CITATION

ARTICLE TOOLS

View Full Article with Supporting Information (HTML) Get PDF (276K)

Keywords:

  • click chemistry;
  • flow chemistry;
  • heterogeneous catalysis;
  • high-throughput screening;
  • high-throughput synthesis;
  • microreactors

Graphical Abstract

Thumbnail image of graphical abstract

Abstract

A library of 1,4-disubstituted 1,2,3-triazoles was synthesized using a copper flow reactor. Organic azides, generated in situ from alkyl halides and sodium azide, were reacted with acetylenes using the copper-catalyzed Huisgen 1,3-dipolar cycloaddition. This process eliminates both the handling of organic azides and the need for additional copper catalyst and permits the facile preparation of numerous triazoles in a continuous flow process.

View Full Article with Supporting Information (HTML) Get PDF (276K)