Palladium-Catalyzed Asymmetric Allylic Alkylation of 2,3-Allenyl Acetates Using a Chiral Diaminophosphine Oxide



An enantioselective synthesis of allenes through palladium-catalyzed asymmetric allylic alkylation using a chiral diaminophosphine oxide is described. The asymmetric allylic alkylations proceeded in the presence of a catalytic amount of lithium acetate at 4 °C, affording the chiral allenes in excellent yield with up to 99% ee.