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Keywords:

  • allenes;
  • asymmetric allylic alkylation;
  • asymmetric catalysis;
  • diaminophosphine oxides;
  • palladium

Abstract

An enantioselective synthesis of allenes through palladium-catalyzed asymmetric allylic alkylation using a chiral diaminophosphine oxide is described. The asymmetric allylic alkylations proceeded in the presence of a catalytic amount of lithium acetate at 4 °C, affording the chiral allenes in excellent yield with up to 99% ee.