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Semiconductor-Gold Nanocomposite Catalysts for the Efficient Three-Component Coupling of Aldehyde, Amine and Alkyne in Water

  1. Leng Leng Chng,
  2. Jun Yang,
  3. Yifeng Wei,
  4. Jackie Y. Ying

Article first published online: 18 NOV 2009

DOI: 10.1002/adsc.200900518

Issue

Advanced Synthesis & Catalysis

Advanced Synthesis & Catalysis

Volume 351, Issue 17, pages 2887–2896, November 2009

Additional Information

How to Cite

Chng, L. L., Yang, J., Wei, Y. and Ying, Jackie Y. (2009), Semiconductor-Gold Nanocomposite Catalysts for the Efficient Three-Component Coupling of Aldehyde, Amine and Alkyne in Water. Adv. Synth. Catal., 351: 2887–2896. doi: 10.1002/adsc.200900518

Author Information

  1. Institute of Bioengineering and Nanotechnology, 31 Biopolis Way, The Nanos, Singapore 138669, Fax: (+65)-6478-9020

Publication History

  1. Issue published online: 24 NOV 2009
  2. Article first published online: 18 NOV 2009
  3. Manuscript Revised: 5 OCT 2009
  4. Manuscript Received: 27 JUL 2009

Funded by

  • Institute of Bioengineering and Nanotechnology (Biomedical Research Council, Agency for Science, Technology and Research, Singapore)

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Keywords:

  • alkynes;
  • gold;
  • heterogeneous catalysis;
  • multicomponent reactions;
  • nanocomposite catalysts

Abstract

An efficient heterogeneous lead sulfide-gold catalyst has been successfully developed for the synthesis of propargylic amines via a three-component coupling reaction of aldehyde, amine and alkyne in water. The process is simple and applicable to a diverse range of aromatic and aliphatic aldehydes, amines and alkynes. Furthermore, the catalyst is stable to air and water, and can be easily recovered and reused.

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