Organocatalytic Asymmetric Synthesis of Protected α,β-Diamino Acids

Authors

  • Zugui Shi,

    1. Division of Chemistry & Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, 21 Nanyang Link, Singapore 637371, Singapore, Fax: (+65)-6791-1961; phone: (+65)-6316-8761
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  • Peiyuan Yu,

    1. Division of Chemistry & Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, 21 Nanyang Link, Singapore 637371, Singapore, Fax: (+65)-6791-1961; phone: (+65)-6316-8761
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  • Pei Juan Chua,

    1. Division of Chemistry & Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, 21 Nanyang Link, Singapore 637371, Singapore, Fax: (+65)-6791-1961; phone: (+65)-6316-8761
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  • Guofu Zhong

    1. Division of Chemistry & Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, 21 Nanyang Link, Singapore 637371, Singapore, Fax: (+65)-6791-1961; phone: (+65)-6316-8761
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Abstract

In the presence of the readily available quinine-derived catalyst 4d, highly diastereo- and enantioselective Mannich reactions of tosyl-protected imines and α-isothiocyanato imides proceeded to afford the protected α,β-diamino acids, useful building blocks for natural products and biologically active compounds, in good to excellent yields.

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