1615-4169/asset/2258_left.gif?v=1&s=480b85eb3acd0e8f47639c75e9ec7a59d53cd074)
Communication
Organocatalytic Asymmetric Synthesis of Protected α,β-Diamino Acids
Article first published online: 12 NOV 2009
DOI: 10.1002/adsc.200900580
Copyright © 2009 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Additional Information
How to Cite
Shi, Z., Yu, P., Chua, P. J. and Zhong, G. (2009), Organocatalytic Asymmetric Synthesis of Protected α,β-Diamino Acids. Adv. Synth. Catal., 351: 2797–2800. doi: 10.1002/adsc.200900580
Publication History
- Issue published online: 24 NOV 2009
- Article first published online: 12 NOV 2009
- Manuscript Received: 23 AUG 2009
Funded by
- Ministry of Education
- Nanyang Technological University
Keywords:
- asymmetric catalysis;
- α,β-diamino acids;
- Mannich reaction;
- organocatalysis;
- quinine derivatives
Abstract
In the presence of the readily available quinine-derived catalyst 4d, highly diastereo- and enantioselective Mannich reactions of tosyl-protected imines and α-isothiocyanato imides proceeded to afford the protected α,β-diamino acids, useful building blocks for natural products and biologically active compounds, in good to excellent yields.