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Keywords:

  • asymmetric catalysis;
  • enantioselectivity;
  • hydrogenation;
  • ruthenium

Abstract

A highly efficient strategy for the synthesis of a series of C3*-TunePhos chiral diphosphine ligands was well established with several remarkable features. The synthetic utility of these ligands was explored for the ruthenium-catalyzed asymmetric hydrogenation of β-keto esters. Up to 99% ee values were achieved for the enantioselective synthesis of β-hydroxy acid derivatives, which are very important chiral building blocks for the synthesis of a variety of natural products and biologically active molecules.