Communication

Copper-Catalyzed One-Pot Synthesis of Substituted Benzimidazoles

  1. Hongwei Jin1,2,
  2. Xiaoliang Xu2,
  3. Jianrong Gao2,
  4. Jianhua Zhong1,
  5. Yanguang Wang1

Article first published online: 5 FEB 2010

DOI: 10.1002/adsc.200900706

Issue

Advanced Synthesis & Catalysis

Advanced Synthesis & Catalysis

Volume 352, Issue 2-3, pages 347–350, February 15, 2010

Additional Information

How to Cite

Jin, H., Xu, X., Gao, J., Zhong, J. and Wang, Y. (2010), Copper-Catalyzed One-Pot Synthesis of Substituted Benzimidazoles. Adv. Synth. Catal., 352: 347–350. doi: 10.1002/adsc.200900706

Author Information

  1. 1

    Department of Chemistry, Zhejiang University, Hangzhou 310027, People's Republic of China, Fax: (+86)-571-8795-1512

  2. 2

    College of Chemical Engineering and Materials Science, Zhejiang University of Technology, Hangzhou 310014, People's Republic of China

Publication History

  1. Issue published online: 17 FEB 2010
  2. Article first published online: 5 FEB 2010
  3. Manuscript Revised: 16 DEC 2009
  4. Manuscript Received: 11 OCT 2009

Funded by

  • National Natural Science Foundation of China. Grant Number: 20872128
  • Scientific Research Fund of Educational Bureau of Zhejiang Province. Grant Number: 20070304

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Keywords:

  • arylation;
  • benzimidazoles;
  • cascade reactions;
  • copper catalysts;
  • multicomponent reactions

Abstract

A copper-catalyzed one-pot synthesis of functionalized benzimidazoles has been developed. The procedure combines the copper-catalyzed three-component cascade reaction of sulfonyl azides, alkynes and 2-bromoaniline and the copper-catalyzed intramolecular N-arylation of sulfonamides in one sequence, which afforded the products in moderate to good yields.

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