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Communication
Highly Efficient One-Pot Synthesis of 2-Substituted Quinazolines and 4H-Benzo[d][1,3]oxazines via Cross Dehydrogenative Coupling using Sodium Hypochlorite
Article first published online: 10 FEB 2010
DOI: 10.1002/adsc.200900715
Copyright © 2010 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Additional Information
How to Cite
Maheswari, C. U., Kumar, G. S., Venkateshwar, M., Kumar, R. A., Kantam, M. L. and Reddy, K. R. (2010), Highly Efficient One-Pot Synthesis of 2-Substituted Quinazolines and 4H-Benzo[d][1,3]oxazines via Cross Dehydrogenative Coupling using Sodium Hypochlorite. Adv. Synth. Catal., 352: 341–346. doi: 10.1002/adsc.200900715
Publication History
- Issue published online: 17 FEB 2010
- Article first published online: 10 FEB 2010
- Manuscript Revised: 1 JAN 2010
- Manuscript Received: 15 OCT 2009
Funded by
- Council of Scientific Industrial Research (CSIR)
Keywords:
- 2-aryl-4H-benzo[d][1,3]oxazines;
- dehydrogenation;
- oxidation;
- quinazolines;
- sodium hypochlorite
Abstract
This communication describes a catalyst-free synthesis of 2-substituted quinazolines and 4H-benzo[d][1,3]oxazines using commericially available sodium hypochlorite as oxidant. Operational simplicity, mild reaction conditions and the ability to construct structurally diverse 2-quinazolines and 2-substituted 4H-benzo[d][1,3]oxazines by this method render it to be a practical alternative for the synthesis of these heterocycles.