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Palladium-Catalyzed Monoselective Halogenation of C[BOND]H Bonds: Efficient Access to Halogenated Arylpyrimidines using Calcium Halides

  1. Bingrui Song,
  2. Xiaojian Zheng,
  3. Jun Mo,
  4. Bin Xu

Article first published online: 5 FEB 2010

DOI: 10.1002/adsc.200900778

Issue

Advanced Synthesis & Catalysis

Advanced Synthesis & Catalysis

Volume 352, Issue 2-3, pages 329–335, February 15, 2010

Additional Information

How to Cite

Song, B., Zheng, X., Mo, J. and Xu, B. (2010), Palladium-Catalyzed Monoselective Halogenation of C[BOND]H Bonds: Efficient Access to Halogenated Arylpyrimidines using Calcium Halides. Adv. Synth. Catal., 352: 329–335. doi: 10.1002/adsc.200900778

Author Information

  1. Department of Chemistry, Shanghai University, 99 Shangda Road, Shanghai 200444, People's Republic of China, Fax: (+86)-21-6613-2797; phone: (+86)-21-6613-2065

Publication History

  1. Issue published online: 17 FEB 2010
  2. Article first published online: 5 FEB 2010
  3. Manuscript Received: 9 NOV 2009

Funded by

  • National Natural Science Foundation of China. Grant Numbers: 20672071, 20972093
  • Shanghai Pujiang Program. Grant Number: 07pj14043
  • Shanghai Municipal Education Commission. Grant Numbers: J50102, 10YZ06

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Keywords:

  • arylpyrimidines;
  • C[BOND]H activation;
  • electron-deficient substrates;
  • halogenation;
  • palladium;
  • selectivity

Abstract

A wide variety of ortho-halogenated arylpyrimidines were prepared with high monoselectivity and functional-group tolerance by using calcium halides as crucial halogenating agents and cupric trifluoroacetate as oxidant in the presence of air.

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