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Keywords:

  • arylpyrimidines;
  • C[BOND]H activation;
  • electron-deficient substrates;
  • halogenation;
  • palladium;
  • selectivity

Abstract

A wide variety of ortho-halogenated arylpyrimidines were prepared with high monoselectivity and functional-group tolerance by using calcium halides as crucial halogenating agents and cupric trifluoroacetate as oxidant in the presence of air.