Highly Enantioselective Amination Reactions of Fluorinated Keto Esters Catalyzed by Novel Chiral Guanidines Derived from Cinchona Alkaloids

Authors

  • Xiao Han,

    1. Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore 117543, Republic of Singapore, Fax: (+65)-6779-1691; phone: (+65)-6516-1569
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  • Fangrui Zhong,

    1. Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore 117543, Republic of Singapore, Fax: (+65)-6779-1691; phone: (+65)-6516-1569
    2. Medicinal Chemistry Program, Life Sciences Institute, National University of Singapore, Republic of Singapore
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  • Yixin Lu

    1. Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore 117543, Republic of Singapore, Fax: (+65)-6779-1691; phone: (+65)-6516-1569
    2. Medicinal Chemistry Program, Life Sciences Institute, National University of Singapore, Republic of Singapore
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Abstract

Novel Cinchona alkaloid-derived guanidines catalyze stereoselective aminations of fluorinated keto esters, affording products with fluorine-containing quaternary stereogenic centers in excellent yields and with moderate to high enantioselectivities.

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