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Keywords:

  • asymmetric amination;
  • chiral guanidines;
  • Cinchona alkaloids;
  • fluorination substituent;
  • organocatalysis

Abstract

Novel Cinchona alkaloid-derived guanidines catalyze stereoselective aminations of fluorinated keto esters, affording products with fluorine-containing quaternary stereogenic centers in excellent yields and with moderate to high enantioselectivities.