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Keywords:

  • ammonium formate;
  • chemoselectivity;
  • gold;
  • heterogeneous catalysis;
  • N-formylation;
  • nitro group reduction

Abstract

A highly chemo- and regioselective reduction of a wide diversity of aromatic nitro compounds to the corresponding amines has been achieved by a combination of gold nanoparticles supported on titania and ammonium formate (HCOONH4) in ethanol at room temperature. Furthermore, a direct and mild route to formanilides from aromatic nitro compounds bearing different functional groups by reductive N-formylation using the gold-mediated transfer reduction protocol is also established.