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Communication
Efficient Iron-Catalyzed Direct β-Alkylation of Secondary Alcohols with Primary Alcohols
Article first published online: 9 FEB 2012
DOI: 10.1002/adsc.201000907
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Additional Information
How to Cite
Yang, J., Liu, X., Meng, D.-L., Chen, H.-Y., Zong, Z.-H., Feng, T.-T. and Sun, K. (2012), Efficient Iron-Catalyzed Direct β-Alkylation of Secondary Alcohols with Primary Alcohols. Adv. Synth. Catal., 354: 328–334. doi: 10.1002/adsc.201000907
Publication History
- Issue published online: 17 FEB 2012
- Article first published online: 9 FEB 2012
- Manuscript Revised: 20 SEP 2011
- Manuscript Received: 2 DEC 2010
Funded by
- Foundation of Sci-tech Development Project of Jilin Province. Grant Number: Scientific Research Foundation for Youth Scholars, No. 20100135
- Basic Professional Foundation for Scientific Research of Jilin University. Grant Number: 200903351
Keywords:
- alkylation;
- C
![[BOND]](http://onlinelibrarystatic.wiley.com/undisplayable_characters/00f8ff.gif)
C coupling; - iron;
- primary alcohols;
- secondary alcohols
Abstract
The efficient iron-catalyzed direct β-alkylation of secondary alcohols with primary alcohols is described. In the presence of the commercially available iron catalyst (ferrocenecarboxaldehyde, 1b) and a catalytic amount of base, the reactions give β-alkylated higher alcohols in high yields in the absence of any sacrificial agents (hydrogen acceptors or hydrogen donors) and nitrogen or phosphorus ligands. For the first time, iron is employed as an inexpensive and environmentally benign alternative with high atom efficiency to noble metal-based catalysts in this type of reaction.