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Novel 2,2,6,6-Tetramethylpiperidine 1-Oxyl–Iodobenzene Hybrid Catalyst for Oxidation of Primary Alcohols to Carboxylic Acids

Authors

  • Takayuki Yakura,

    Corresponding author
    1. Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Sugitani, Toyama 930-0194, Japan, Fax: (+81)-76-434-7558; phone: (+81)-76-434-7558
    • Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Sugitani, Toyama 930-0194, Japan, Fax: (+81)-76-434-7558; phone: (+81)-76-434-7558
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  • Ayaka Ozono

    1. Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Sugitani, Toyama 930-0194, Japan, Fax: (+81)-76-434-7558; phone: (+81)-76-434-7558
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Abstract

Novel bifunctional hybrid-type catalysts bearing 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO) and iodobenzene moieties (1a and 1b) were developed and used for the environmentally benign oxidation of primary alcohols to carboxylic acids. Reaction of primary alcohols 2 with a catalytic amount of 1 in the presence of peracetic acid as a co-oxidant under mild conditions gave the corresponding carboxylic acids 3 in excellent yields.

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