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Keywords:

  • amidines;
  • amination;
  • aminomethylation;
  • benzoxazoles;
  • three-component coupling

Abstract

A method for the selective synthesis of amidines by ring-opening amination or of 7-aminomethylbenzoxazoles via a novel three-component-coupling reaction (arene, dichloromethane and amine) from benzoxazoles and amines was developed. Amidines could be further converted into 2-aminobenzoxazoles in high yield.