Communication

C[BOND]X (X=Br, I) Bond-Tolerant Aerobic Oxidative Cross- Coupling: A Strategy to Selectively Construct β-Aryl Ketones and Aldehydes

  1. Mao Chen1,
  2. Jie Wang1,
  3. Ziyi Chai1,
  4. Cai You1,
  5. Aiwen Lei1,2,*

Article first published online: 9 FEB 2012

DOI: 10.1002/adsc.201100782

Issue

Advanced Synthesis & Catalysis

Advanced Synthesis & Catalysis

Volume 354, Issue 2-3, pages 341–346, February 2012

Additional Information

How to Cite

Chen, M., Wang, J., Chai, Z., You, C. and Lei, A. (2012), C[BOND]X (X=Br, I) Bond-Tolerant Aerobic Oxidative Cross- Coupling: A Strategy to Selectively Construct β-Aryl Ketones and Aldehydes. Adv. Synth. Catal., 354: 341–346. doi: 10.1002/adsc.201100782

Author Information

  1. 1

    College of the Chemistry and Molecular Sciences, Wuhan University ,Wuhan, Hubei 430072, People's Republic of China, Fax: (+86)-27-6875-4067

  2. 2

    State Key Laboratory for Oxo Synthesis and Selective Oxidation, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, People's Republic of China

*College of the Chemistry and Molecular Sciences, Wuhan University ,Wuhan, Hubei 430072, People's Republic of China, Fax: (+86)-27-6875-4067

Publication History

  1. Issue published online: 17 FEB 2012
  2. Article first published online: 9 FEB 2012
  3. Manuscript Received: 8 OCT 2011

Funded by

  • National Natural Science Foundation of China. Grant Number: 20702040, 20832003, 20972118

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Keywords:

  • copper;
  • cross-coupling;
  • oxygen;
  • palladium;
  • selectivity

Abstract

Using moelcular oxygen as the terminal oxidant, various aryl halide-containing β-aryl ketones and aldehydes can be synthesized directly from readily available allyic alcohols and boronic acids via palladium-catalyzed oxidative cross-coupling reactions. The dual roles of copper, including electron-carrier and Lewis acid functions, are supposed to be critical for the high reactivity and selectivity of this aerobic oxidative coupling transformation.

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