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Nickel-Catalyzed Cross-Coupling of Arene- or Heteroarenecarbonitriles with Aryl- or Heteroarylmanganese Reagents through C[BOND]CN Bond Activation

Authors

  • Ning Liu,

    1. CAS Key Laboratory of Soft Matter Chemistry and Department of Chemistry, University of Science and Technology of China, Hefei, Anhui 230026, People's Republic of China, Fax: (+86)-551-360-1592
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  • Zhong-Xia Wang

    Corresponding author
    1. CAS Key Laboratory of Soft Matter Chemistry and Department of Chemistry, University of Science and Technology of China, Hefei, Anhui 230026, People's Republic of China, Fax: (+86)-551-360-1592
    • CAS Key Laboratory of Soft Matter Chemistry and Department of Chemistry, University of Science and Technology of China, Hefei, Anhui 230026, People's Republic of China, Fax: (+86)-551-360-1592
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Abstract

The nickel-catalyzed cross-coupling reaction of arene- or heteroarenecarbonitriles with aryl- or heteroarylmanganese reagents via C[BOND]CN bond activation has been developed. Both electron-rich and electron-deficient nitriles can be employed as the electrophilic substrates. The reaction tolerates a range of functional groups and aromatic heterocycles.

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