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General, Green, and Scalable Synthesis of Imines from Alcohols and Amines by a Mild and Efficient Copper-Catalyzed Aerobic Oxidative Reaction in Open Air at Room Temperature

Authors

  • Haiwen Tian,

    1. College of Chemistry and Materials Engineering, Wenzhou University, Wenzhou, Zhejiang 325035, People's Republic of China, Fax: (+86)-577-8668-9300; phone: (+86)-138-5774-5327
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  • Xiaochun Yu,

    1. College of Chemistry and Materials Engineering, Wenzhou University, Wenzhou, Zhejiang 325035, People's Republic of China, Fax: (+86)-577-8668-9300; phone: (+86)-138-5774-5327
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  • Qiang Li,

    1. College of Chemistry and Materials Engineering, Wenzhou University, Wenzhou, Zhejiang 325035, People's Republic of China, Fax: (+86)-577-8668-9300; phone: (+86)-138-5774-5327
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  • Jianxin Wang,

    1. College of Chemistry and Materials Engineering, Wenzhou University, Wenzhou, Zhejiang 325035, People's Republic of China, Fax: (+86)-577-8668-9300; phone: (+86)-138-5774-5327
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  • Qing Xu

    Corresponding author
    1. College of Chemistry and Materials Engineering, Wenzhou University, Wenzhou, Zhejiang 325035, People's Republic of China, Fax: (+86)-577-8668-9300; phone: (+86)-138-5774-5327
    • College of Chemistry and Materials Engineering, Wenzhou University, Wenzhou, Zhejiang 325035, People's Republic of China, Fax: (+86)-577-8668-9300; phone: (+86)-138-5774-5327
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Abstract

A general, green, and scalable synthesis of the useful imines and α,β-unsaturated imines is successfully achieved by a low-loading and powerful, mild and efficient copper-catalyzed aerobic oxidative reaction of alcohols and amines in the open air at room temperature under base- and dehydrating reagent-free conditions. This practical reaction can use air as the economic and green oxidant, tolerates a wide range of substrates, can afford high yields of the target imines on a large scale, and produces water as the only by-product, and thus being the best imination method as yet using alcohols and amines directly.

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