Get access

Enantioselective Mukaiyama–Michael Reaction of Silyl Enol Ethers to 2-Enoylpyridine N-Oxides Catalyzed by Copper- Bis(oxazoline) Complex

Authors

  • Jimil George,

    1. Natural Product Chemistry, CSIR–Indian Institute of Chemical Technology, Hyderabad – 500007, India, Fax: (+91)-40-2716-0512
    Search for more papers by this author
  • Basi V. Subba Reddy

    Corresponding author
    1. Natural Product Chemistry, CSIR–Indian Institute of Chemical Technology, Hyderabad – 500007, India, Fax: (+91)-40-2716-0512
    • Natural Product Chemistry, CSIR–Indian Institute of Chemical Technology, Hyderabad – 500007, India, Fax: (+91)-40-2716-0512
    Search for more papers by this author

Abstract

A catalytic enantioselective Mukaiyama–Michael reaction of 2-enoylpyridine N-oxides has been developed using a simple bis(oxazoline)-copper complex. A variety of silyl enol ethers undergo smooth Michael addition with 2-enoylpyridine N-oxides to furnish the corresponding Michael adducts in high yields with high enantioselectivities (up to 97% ee).

Ancillary