Cross-Coupling in Flow using Supported Catalysts: Mild, Clean, Efficient and Sustainable Suzuki–Miyaura Coupling in a Single Pass

Authors

  • Juan de M. Muñoz,

    1. Janssen Research and Development, Janssen-Cilag, S.A., C/Jarama 75, 45007 Toledo, Spain, Fax: (+34)-92-524-5771; phone: (+34)-92-524-5750
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  • Jesús Alcázar,

    Corresponding author
    1. Janssen Research and Development, Janssen-Cilag, S.A., C/Jarama 75, 45007 Toledo, Spain, Fax: (+34)-92-524-5771; phone: (+34)-92-524-5750
    • Janssen Research and Development, Janssen-Cilag, S.A., C/Jarama 75, 45007 Toledo, Spain, Fax: (+34)-92-524-5771; phone: (+34)-92-524-5750
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  • Antonio de la Hoz,

    1. Facultad de Ciencias Químicas, Universidad de Castilla – La Mancha, Avda. Camilo José Cela, 10, 13071 Ciudad Real, Spain
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  • Angel Díaz-Ortiz

    1. Facultad de Ciencias Químicas, Universidad de Castilla – La Mancha, Avda. Camilo José Cela, 10, 13071 Ciudad Real, Spain
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Abstract

A mild, clean, practical, sustainable and high yielding procedure for Suzuki–Miyaura cross-coupling in a single pass using a silica-supported palladium catalyst is described. The catalyst can be used in more than 30 reactions and for more than 8 h of continuous processing without a decrease in reactivity due to the low leaching observed. Different halides/pseudo-halides and organoboron compounds can be used without modifying the standard procedure.

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