Organocatalytic Asymmetric Addition of Thiols to Trifluoromethylaldimine: An Efficient Approach to Chiral Trifluoromethylated N,S-Acetals

Authors

  • Xin Fang,

    1. College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072, People's Republic of China, Fax: (+86)-27-6875-4067
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  • Qing-Hua Li,

    1. College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072, People's Republic of China, Fax: (+86)-27-6875-4067
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  • Hai-Yan Tao,

    1. College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072, People's Republic of China, Fax: (+86)-27-6875-4067
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  • Chun-Jiang Wang

    Corresponding author
    1. College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072, People's Republic of China, Fax: (+86)-27-6875-4067
    2. State Key Laboratory of Elemento-organic Chemistry, Nankai University, Tianjin 300071, People's Republic of China
    • College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072, People's Republic of China, Fax: (+86)-27-6875-4067
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Abstract

The first organocatalytic asymmetric addition of thiols to trifluoromethylaldimine for the construction of chiral trifluoromethylated N,S-acetals has been achieved in high yields (up to 99%) and excellent enantioselectivities (up to 95% ee) with 1 mol% of a bifunctional organocatalyst.

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