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Keywords:

  • acylation;
  • N-benzyltriflamides;
  • catalysis;
  • C[BOND]H activation;
  • palladium

Abstract

A palladium-catalyzed ortho-acylation of N-benzyltriflamides with aldehydes via direct sp2 C[BOND]H bond activation is described. Benzylamines with a triflamide directing group in the presence of palladium acetate, acetic acid, and tert-butyl hydroperoxide as an oxidant can be effectively coupled with aryl and alkyl aldehydes to provide ortho-acyl-N-benzyltriflamides with a high regioselectivity.