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Keywords:

  • asymmetric hydrogenation;
  • BIPI ligands;
  • naphthalenes;
  • peri position;
  • unfunctionalized olefins

Abstract

The modular nature of the BIPI ligands allows for systematic optimization of each ligand region. The development of ligands optimized for asymmetric hydrogenation of the challenging unfunctionalized olefin substrate class is described. The naphthyl peri position, C-8, has been identified as a critical stereocontrol element in the design of these ligands. Highly enantioselective ligands suitable for hydrogenation of tri- and tetrasubstituted olefins are detailed.