Rhodium(III)-Catalyzed C(sp2)[BOND]H Activation and Electrophilic Amidation with N-Fluorobenzenesulfonimide

Authors

  • Ren-Jin Tang,

    1. Key Laboratory for Environmentally Friendly Chemistry and Application of the Ministry of Education, Department of Chemistry, Xiangtan University, Hunan 411105, People's Republic of China, Fax: (+86)-731-5829-2251; phone: (+86)-731-5829-8351
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  • Cui-Ping Luo,

    1. Key Laboratory for Environmentally Friendly Chemistry and Application of the Ministry of Education, Department of Chemistry, Xiangtan University, Hunan 411105, People's Republic of China, Fax: (+86)-731-5829-2251; phone: (+86)-731-5829-8351
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  • Luo Yang,

    Corresponding author
    1. Key Laboratory for Environmentally Friendly Chemistry and Application of the Ministry of Education, Department of Chemistry, Xiangtan University, Hunan 411105, People's Republic of China, Fax: (+86)-731-5829-2251; phone: (+86)-731-5829-8351
    • Key Laboratory for Environmentally Friendly Chemistry and Application of the Ministry of Education, Department of Chemistry, Xiangtan University, Hunan 411105, People's Republic of China, Fax: (+86)-731-5829-2251; phone: (+86)-731-5829-8351
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  • Chao-Jun Li

    Corresponding author
    1. Department of Chemistry, McGill University, Montreal, QC, Canada H3A 2K6, Fax: (+1)-514-398-8457; phone: (+1)-514-398-3797
    • Department of Chemistry, McGill University, Montreal, QC, Canada H3A 2K6, Fax: (+1)-514-398-8457; phone: (+1)-514-398-3797
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Abstract

An electrophilic amidation via a cationic rhodium(III)-catalyzed C(sp2)[BOND]H activation has been developed with the commercially available N-fluorobenzenesulfonimide as the amino source under external oxidant-free conditions. This amidation requires only a catalytic amount of base and exhibits excellent functional group tolerance and regioselectivity, providing a new avenue in direct C(sp2)[BOND]H amidation.

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