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Keywords:

  • amidation;
  • C(sp2)[BOND]H activation;
  • cationic rhodium(III);
  • N-fluorobenzenesulfonimide

Abstract

An electrophilic amidation via a cationic rhodium(III)-catalyzed C(sp2)[BOND]H activation has been developed with the commercially available N-fluorobenzenesulfonimide as the amino source under external oxidant-free conditions. This amidation requires only a catalytic amount of base and exhibits excellent functional group tolerance and regioselectivity, providing a new avenue in direct C(sp2)[BOND]H amidation.