Efficient Oxidative Chlorination of Aromatics on Saturated Sodium Chloride Solution

Authors

  • Liuqun Gu,

    1. Department of Pharmaceutical Synthesis and Green Chemistry, Institute of Bioengineering and Nanotechnology, 31 Biopolis Way, The Nanos, Singapore 138669, Fax: (+65)-6478-9080
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  • Ting Lu,

    1. Department of Pharmaceutical Synthesis and Green Chemistry, Institute of Bioengineering and Nanotechnology, 31 Biopolis Way, The Nanos, Singapore 138669, Fax: (+65)-6478-9080
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  • Mingyun Zhang,

    1. Department of Pharmaceutical Synthesis and Green Chemistry, Institute of Bioengineering and Nanotechnology, 31 Biopolis Way, The Nanos, Singapore 138669, Fax: (+65)-6478-9080
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  • Lijuan Tou,

    1. Department of Pharmaceutical Synthesis and Green Chemistry, Institute of Bioengineering and Nanotechnology, 31 Biopolis Way, The Nanos, Singapore 138669, Fax: (+65)-6478-9080
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  • Yugen Zhang

    Corresponding author
    1. Department of Pharmaceutical Synthesis and Green Chemistry, Institute of Bioengineering and Nanotechnology, 31 Biopolis Way, The Nanos, Singapore 138669, Fax: (+65)-6478-9080
    • Department of Pharmaceutical Synthesis and Green Chemistry, Institute of Bioengineering and Nanotechnology, 31 Biopolis Way, The Nanos, Singapore 138669, Fax: (+65)-6478-9080
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Abstract

An efficient metal-free system using saturated aqueous sodium chloride/aqueous ammonium chloride solution as chlorine source and potassium persulfate as a cheap oxidant for the chlorination of various aromatic compounds including deactivated ones has been developed that proceeds without any acid additive in an excellent regioselective manner. The easy-to-handle aqueous solution/acetonitrile biphasic system as solvent and no need for precautionary measures make this process very practical.

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