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Keywords:

  • allylic substitution;
  • chemoselectivity;
  • dearomatization;
  • naphthalenones;
  • naphthols;
  • palladium

Abstract

Thumbnail image of graphical abstract

A highly efficient dearomatization reaction of α-substituted β-naphthols with excellent chemoselectivity and regioselectivity has been developed. Mechanistic studies demonstrated that the dearomatized alkylation product is the thermodynamically more stable compound. The etherification product could be further transformed to the dearomatization product.