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Application of Langlois’ Reagent in Trifluoromethylation Reactions

Authors

  • Cai Zhang

    Corresponding author
    1. Department of Resources and Environment, Chongqing Vocational Institute of Safety Technology, Wanzhou District, Chongqing, People's Republic of China, Fax: (+86)-23-5856-7750; phone: (+86)-23-5856-7778
    • Department of Resources and Environment, Chongqing Vocational Institute of Safety Technology, Wanzhou District, Chongqing, People's Republic of China, Fax: (+86)-23-5856-7750; phone: (+86)-23-5856-7778

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Abstract

The incorporation of a trifluoromethyl (CF3) group into organic compounds is of great importance in pharmaceutical, agricultural, and materials science. Trifluoromethylation based on radical intermediates, as a valuable alternative transformation using the inexpensive and stable solid sodium trifluoromethanesulfinate (CF3SO2Na; Langlois’ reagent), has attracted much attention and has become a hot research field. This review examines recent advances in radical trifluoromethylation reactions with CF3SO2Na as CF3 source.

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