Advanced Synthesis & Catalysis

Cover image for Vol. 353 Issue 8

May 2011

Volume 353, Issue 8

Pages 1189–1391

  1. Cover Picture

    1. Top of page
    2. Cover Picture
    3. Contents
    4. Commentary
    5. Communications
    6. Full Papers
    7. Retraction
    1. Cover Picture: (Adv. Synth. Catal. 8/2011) (page 1189)

      Article first published online: 24 MAY 2011 | DOI: 10.1002/adsc.201190018

      Thumbnail image of graphical abstract

      The cover picture, provided by Fandrick, Fandrick, and Senanayake, depicts the copper-catalyzed asymmetric propargylation of aldehydes. The process is based on a copper alkoxide-promoted B/Cu exchange to generate an allenyl copper intermediate. The process is initiated by ligand exchange of the ligated copper(II) isobutyrate complex with lithium tert-butoxide, wherein the resulting copper alkoxide complex undergoes an exchange with the propargyl borolane reagent to generate the key allenyl copper intermediate. After propargylation of an aldehyde, the resulting homopropargylic alkoxide copper complex readily participates in another B/Cu exchange to complete the catalytic cycle. Employing the MeOBIBOP ligand allows for exceptional control of both enantioselectivity and site selectivity for the homopropargylic alcohol. This two-step process, wherein the product of the alkylation readily reacts with a stoichiometric reagent to regenerate the active nucleophile provides an operationally simple process to effect the propargylation of aldehydes with broad functional group tolerance.

  2. Contents

    1. Top of page
    2. Cover Picture
    3. Contents
    4. Commentary
    5. Communications
    6. Full Papers
    7. Retraction
    1. Graphical Abstract: Adv. Synth. Catal. 8/2011 (pages 1191–1197)

      Article first published online: 24 MAY 2011 | DOI: 10.1002/adsc.201190019

  3. Commentary

    1. Top of page
    2. Cover Picture
    3. Contents
    4. Commentary
    5. Communications
    6. Full Papers
    7. Retraction
  4. Communications

    1. Top of page
    2. Cover Picture
    3. Contents
    4. Commentary
    5. Communications
    6. Full Papers
    7. Retraction
  5. Full Papers

    1. Top of page
    2. Cover Picture
    3. Contents
    4. Commentary
    5. Communications
    6. Full Papers
    7. Retraction
    1. A New Class of Heterogeneous Platinum Catalysts for the Chemoselective Hydrogenation of Nitroarenes (pages 1306–1316)

      Valerica Pandarus, Rosaria Ciriminna, François Béland and Mario Pagliaro

      Article first published online: 17 MAY 2011 | DOI: 10.1002/adsc.201000945

      Thumbnail image of graphical abstract
    2. Synthesis, Rhodium Complexes and Catalytic Applications of a New Water-Soluble Triphenylphosphane-Modified β-Cyclodextrin (pages 1325–1334)

      François-Xavier Legrand, Natacha Six, Christian Slomianny, Hervé Bricout, Sébastien Tilloy and Eric Monflier

      Article first published online: 17 MAY 2011 | DOI: 10.1002/adsc.201000917

      Thumbnail image of graphical abstract
    3. Highly Active and Diastereoselective N,O- and N,N-Yttrium Complexes for Intramolecular Hydroamination (pages 1384–1390)

      Frank Lauterwasser, Paul G. Hayes, Warren E. Piers, Laurel L. Schafer and Stefan Bräse

      Article first published online: 17 MAY 2011 | DOI: 10.1002/adsc.201000892

      Thumbnail image of graphical abstract
  6. Retraction

    1. Top of page
    2. Cover Picture
    3. Contents
    4. Commentary
    5. Communications
    6. Full Papers
    7. Retraction
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