Advanced Synthesis & Catalysis

Cover image for Vol. 354 Issue 1

January 2012

Volume 354, Issue 1

Pages 1–222

  1. Cover Picture

    1. Top of page
    2. Cover Picture
    3. Commentary
    4. Contents
    5. Review
    6. Communications
    7. Full Papers
    8. Updates
    1. You have free access to this content
      Cover Picture: (Adv. Synth. Catal. 1/2012) (page 1)

      Article first published online: 20 JAN 2012 | DOI: 10.1002/adsc.201290000

      Thumbnail image of graphical abstract

      The cover picture, provided by Qi-Lin Zhou, shows the example of an exceptionally highly efficient chiral catalyst. The catalyst is a very stable dihydride iridium complex of a tridentate chiral spiro P-N-N ligand based on the 1,1′-spirobiindane skeleton, which exhibits excellent enantioselectivity and extremely high turnover number (in excess of one million) for the hydrogenation of both aryl ketones and β-aryl-β-keto esters. Although little is known about the mechanism of this iridiumcatalyzed carbonyl group hydrogenation reaction, a non-classical metal[BOND]ligand bifunctional mechanism deserves to be recommended to interpret the high efficiency of this catalyst. With the help of KO-t-Bu and under an H2 atmosphere, the dihydride iridium complex is converted to a trihydride iridium complex. After combination of the substrate with the trihydride iridium complex, a cyclic six-membered transition state is formed. The hydridic Ir[BOND]H and protic N[BOND]H of the catalyst are simultaneously transferred to the carbonyl[BOND]oxygen double bond of the substrate, resulting in a chiral alcohol and a hydrido amido iridium complex. Finally, the hydrido amido iridium complex is hydrogenated with H2 to regenerate the trihydride iridium complex.

  2. Commentary

    1. Top of page
    2. Cover Picture
    3. Commentary
    4. Contents
    5. Review
    6. Communications
    7. Full Papers
    8. Updates
    1. You have free access to this content
  3. Contents

    1. Top of page
    2. Cover Picture
    3. Commentary
    4. Contents
    5. Review
    6. Communications
    7. Full Papers
    8. Updates
    1. Graphical Abstract: Adv. Synth. Catal. 1/2012 (pages 9–14)

      Article first published online: 20 JAN 2012 | DOI: 10.1002/adsc.201290001

  4. Review

    1. Top of page
    2. Cover Picture
    3. Commentary
    4. Contents
    5. Review
    6. Communications
    7. Full Papers
    8. Updates
    1. Flow Chemistry – A Key Enabling Technology for (Multistep) Organic Synthesis (pages 17–57)

      Jens Wegner, Sascha Ceylan and Andreas Kirschning

      Article first published online: 12 JAN 2012 | DOI: 10.1002/adsc.201100584

      Thumbnail image of graphical abstract
  5. Communications

    1. Top of page
    2. Cover Picture
    3. Commentary
    4. Contents
    5. Review
    6. Communications
    7. Full Papers
    8. Updates
    1. SIAPhos: Phosphorylated Sulfonimidamides and their Use in Iridium-Catalyzed Asymmetric Hydrogenations of Sterically Hindered Cyclic Enamides (pages 59–64)

      Frederic W. Patureau, Christin Worch, Maxime A. Siegler, Anthony L. Spek, Carsten Bolm and Joost N. H. Reek

      Article first published online: 12 JAN 2012 | DOI: 10.1002/adsc.201100692

      Thumbnail image of graphical abstract
  6. Full Papers

    1. Top of page
    2. Cover Picture
    3. Commentary
    4. Contents
    5. Review
    6. Communications
    7. Full Papers
    8. Updates
    1. Evolutionary Catalyst Screening: Iridium-Catalyzed Imine Hydrogenation (pages 89–95)

      Alexander M. Kluwer, Remko J. Detz, Zohar Abiri, Alida M. van der Burg and Joost N. H. Reek

      Article first published online: 12 JAN 2012 | DOI: 10.1002/adsc.201100422

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    2. Production, Characterization and Synthetic Application of a Purine Nucleoside Phosphorylase from Aeromonas hydrophila (pages 96–104)

      Daniela Ubiali, Carla D. Serra, Immacolata Serra, Carlo F. Morelli, Marco Terreni, Alessandra M. Albertini, Paolo Manitto and Giovanna Speranza

      Article first published online: 12 JAN 2012 | DOI: 10.1002/adsc.201100505

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    3. Stereochemical Outcome of the Biocatalysed Reduction of Activated Tetrasubstituted Olefins by Old Yellow Enzymes 1–3 (pages 105–112)

      Elisabetta Brenna, Francesco G. Gatti, Daniela Monti, Fabio Parmeggiani and Stefano Serra

      Article first published online: 12 JAN 2012 | DOI: 10.1002/adsc.201100504

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    4. On Homogeneous Gold/Palladium Catalytic Systems (pages 133–147)

      A. Stephen K. Hashmi, Christian Lothschütz, René Döpp, Martin Ackermann, Janosc De Buck Becker, Matthias Rudolph, Christian Scholz and Frank Rominger

      Article first published online: 12 JAN 2012 | DOI: 10.1002/adsc.201000044

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  7. Updates

    1. Top of page
    2. Cover Picture
    3. Commentary
    4. Contents
    5. Review
    6. Communications
    7. Full Papers
    8. Updates
    1. Domino Carbopalladation-Carbonylation: Investigation of Substrate Scope (pages 205–216)

      Brinton Seashore-Ludlow, Jakob Danielsson and Peter Somfai

      Article first published online: 13 JAN 2012 | DOI: 10.1002/adsc.201100678

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