Advanced Synthesis & Catalysis

Cover image for Vol. 354 Issue 18

December 14, 2012

Volume 354, Issue 18

Pages 3337–3567

  1. Cover Picture

    1. Top of page
    2. Cover Picture
    3. Contents
    4. Corrigendum
    5. Review
    6. Communications
    7. Full Papers
    8. Updates
    1. You have free access to this content
      Cover Picture: (Adv. Synth. Catal. 18/2012) (page 3337)

      Article first published online: 12 DEC 2012 | DOI: 10.1002/adsc.201290035

      Thumbnail image of graphical abstract

      The cover picture, provided by Qi-Lin Zhou, shows the example of an exceptionally highly efficient chiral catalyst. The catalyst is a very stable dihydride iridium complex of a tridentate chiral spiro P-N-N ligand based on the 1,1′-spirobiindane skeleton, which exhibits excellent enantioselectivity and extremely high turnover number (in excess of one million) for the hydrogenation of both aryl ketones and β-aryl-β-keto esters. Although little is known about the mechanism of this iridiumcatalyzed carbonyl group hydrogenation reaction, a non-classical metal[BOND]ligand bifunctional mechanism deserves to be recommended to interpret the high efficiency of this catalyst. With the help of KO-t-Bu and under an H2 atmosphere, the dihydride iridium complex is converted to a trihydride iridium complex. After combination of the substrate with the trihydride iridium complex, a cyclic six-membered transition state is formed. The hydridic Ir[BOND]H and protic N[BOND]H of the catalyst are simultaneously transferred to the carbonyl[BOND]oxygen double bond of the substrate, resulting in a chiral alcohol and a hydrido amido iridium complex. Finally, the hydrido amido iridium complex is hydrogenated with H2 to regenerate the trihydride iridium complex.

  2. Contents

    1. Top of page
    2. Cover Picture
    3. Contents
    4. Corrigendum
    5. Review
    6. Communications
    7. Full Papers
    8. Updates
    1. Graphical Abstract: Adv. Synth. Catal. 18/2012 (pages 3339–3345)

      Article first published online: 12 DEC 2012 | DOI: 10.1002/adsc.201290036

  3. Corrigendum

    1. Top of page
    2. Cover Picture
    3. Contents
    4. Corrigendum
    5. Review
    6. Communications
    7. Full Papers
    8. Updates
    1. You have free access to this content
  4. Review

    1. Top of page
    2. Cover Picture
    3. Contents
    4. Corrigendum
    5. Review
    6. Communications
    7. Full Papers
    8. Updates
  5. Communications

    1. Top of page
    2. Cover Picture
    3. Contents
    4. Corrigendum
    5. Review
    6. Communications
    7. Full Papers
    8. Updates
    1. From Diols to Lactones under Aerobic Conditions using a Laccase/TEMPO Catalytic System in Aqueous Medium (pages 3405–3408)

      Alba Díaz-Rodríguez, Iván Lavandera, Seda Kanbak-Aksu, Roger A. Sheldon, Vicente Gotor and Vicente Gotor-Fernández

      Article first published online: 4 DEC 2012 | DOI: 10.1002/adsc.201200892

      Thumbnail image of graphical abstract
    2. Water-Soluble Chiral Ruthenium(II) Phenyloxazoline Complex: Reusable and Highly Enantioselective Catalyst for Intramolecular Cyclopropanation Reactions (pages 3435–3439)

      Abdel-Moneim Abu-Elfotoh, Diem Phuong Thi Nguyen, Soda Chanthamath, Kesiny Phomkeona, Kazutaka Shibatomi and Seiji Iwasa

      Article first published online: 4 DEC 2012 | DOI: 10.1002/adsc.201200508

      Thumbnail image of graphical abstract
    3. Highly Active Dinuclear Copper Catalysts for Homogeneous Azide–Alkyne Cycloadditions (pages 3445–3450)

      Regina Berg, Johannes Straub, Ella Schreiner, Steffen Mader, Frank Rominger and Bernd F. Straub

      Article first published online: 28 NOV 2012 | DOI: 10.1002/adsc.201200734

      Thumbnail image of graphical abstract
  6. Full Papers

    1. Top of page
    2. Cover Picture
    3. Contents
    4. Corrigendum
    5. Review
    6. Communications
    7. Full Papers
    8. Updates
    1. Quantitative Comparison of Chiral Catalysts Selectivity and Performance: A Generic Concept Illustrated with Cyclododecanone Monooxygenase as Baeyer–Villiger Biocatalyst (pages 3491–3500)

      Michael J. Fink, Daniela V. Rial, Petra Kapitanova, Alenka Lengar, Jessica Rehdorf, Qiong Cheng, Florian Rudroff and Marko D. Mihovilovic

      Article first published online: 21 NOV 2012 | DOI: 10.1002/adsc.201200453

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    2. Enantioselective Organocatalytic Michael Addition of Cyclobutanones to Nitroalkenes (pages 3523–3532)

      Damien Mailhol, Maria del Mar Sanchez Duque, Wilfried Raimondi, Damien Bonne, Thierry Constantieux, Yoann Coquerel and Jean Rodriguez

      Article first published online: 4 DEC 2012 | DOI: 10.1002/adsc.201200658

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  7. Updates

    1. Top of page
    2. Cover Picture
    3. Contents
    4. Corrigendum
    5. Review
    6. Communications
    7. Full Papers
    8. Updates
    1. Batch Stille Coupling with Insoluble and Recyclable Stannylated Polynorbornenes (pages 3551–3560)

      Sheila Martínez-Arranz, Nora Carrera, Ana C. Albéniz, Pablo Espinet and Alejandro Vidal-Moya

      Article first published online: 4 DEC 2012 | DOI: 10.1002/adsc.201200624

      Thumbnail image of graphical abstract

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