Advanced Synthesis & Catalysis

Cover image for Vol. 354 Issue 4

March 2012

Volume 354, Issue 4

Pages 545–756

  1. Cover Picture

    1. Top of page
    2. Cover Picture
    3. Contents
    4. Communications
    5. Full Papers
    6. Updates
    1. You have free access to this content
      Cover Picture: (Adv. Synth. Catal. 4/2012) (page 545)

      Version of Record online: 7 MAR 2012 | DOI: 10.1002/adsc.201290005

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      The cover picture, provided by Qi-Lin Zhou, shows the example of an exceptionally highly efficient chiral catalyst. The catalyst is a very stable dihydride iridium complex of a tridentate chiral spiro P-N-N ligand based on the 1,1′-spirobiindane skeleton, which exhibits excellent enantioselectivity and extremely high turnover number (in excess of one million) for the hydrogenation of both aryl ketones and β-aryl-β-keto esters. Although little is known about the mechanism of this iridiumcatalyzed carbonyl group hydrogenation reaction, a non-classical metal[BOND]ligand bifunctional mechanism deserves to be recommended to interpret the high efficiency of this catalyst. With the help of KO-t-Bu and under an H2 atmosphere, the dihydride iridium complex is converted to a trihydride iridium complex. After combination of the substrate with the trihydride iridium complex, a cyclic six-membered transition state is formed. The hydridic Ir[BOND]H and protic N[BOND]H of the catalyst are simultaneously transferred to the carbonyl[BOND]oxygen double bond of the substrate, resulting in a chiral alcohol and a hydrido amido iridium complex. Finally, the hydrido amido iridium complex is hydrogenated with H2 to regenerate the trihydride iridium complex.

  2. Contents

    1. Top of page
    2. Cover Picture
    3. Contents
    4. Communications
    5. Full Papers
    6. Updates
  3. Communications

    1. Top of page
    2. Cover Picture
    3. Contents
    4. Communications
    5. Full Papers
    6. Updates
    1. Gold-Catalyzed Synthesis of Dibenzopentalenes – Evidence for Gold Vinylidenes (pages 555–562)

      A. Stephen K. Hashmi, Marcel Wieteck, Ingo Braun, Pascal Nösel, Linda Jongbloed, Matthias Rudolph and Frank Rominger

      Version of Record online: 23 FEB 2012 | DOI: 10.1002/adsc.201200086

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    2. Activation of 1,2-Keto Esters with Takemoto’s Catalyst toward Michael Addition to Nitroalkenes (pages 563–568)

      Wilfried Raimondi, Olivier Baslé, Thierry Constantieux, Damien Bonne and Jean Rodriguez

      Version of Record online: 23 FEB 2012 | DOI: 10.1002/adsc.201100739

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    3. Selective Aerobic Oxidation of Alcohols by Using Manganese Oxide Nanoparticles as an Efficient Heterogeneous Catalyst (pages 569–573)

      Hua-yin Sun, Qing Hua, Feng-feng Guo, Zhi-yong Wang and Wei-xin Huang

      Version of Record online: 23 FEB 2012 | DOI: 10.1002/adsc.201100666

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    4. Iron-Catalyzed Nitrogen-Directed Coupling of Arene and Aryl Bromides Mediated by Metallic Magnesium (pages 593–596)

      Laurean Ilies, Motoaki Kobayashi, Arimasa Matsumoto, Naohiko Yoshikai and Eiichi Nakamura

      Version of Record online: 23 FEB 2012 | DOI: 10.1002/adsc.201100791

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    5. Diastereoselective Synthesis of N-Substituted Planar Chiral Ferrocenes Using a Proline Hydantoin-Derived Auxiliary (pages 602–606)

      Costa Metallinos, Joshni John, Josh Zaifman and Kassandra Emberson

      Version of Record online: 23 FEB 2012 | DOI: 10.1002/adsc.201100862

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  4. Full Papers

    1. Top of page
    2. Cover Picture
    3. Contents
    4. Communications
    5. Full Papers
    6. Updates
    1. Chemoselective Hydrogenation of the Olefinic Bonds Using a Palladium/Magnesium-Lanthanum Mixed Oxide Catalyst (pages 663–669)

      Mannepalli Lakshmi Kantam, Ramineni Kishore, Jagjit Yadav, Medak Sudhakar and Akula Venugopal

      Version of Record online: 23 FEB 2012 | DOI: 10.1002/adsc.201100569

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    2. Formation of Acetals under Rhodium-Catalyzed Hydroformylation Conditions in Alcohols (pages 670–677)

      Olivier Diebolt, Clément Cruzeuil, Christian Müller and Dieter Vogt

      Version of Record online: 23 FEB 2012 | DOI: 10.1002/adsc.201100707

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    3. Iron-Catalysed Markovnikov Hydrothiolation of Styrenes (pages 678–687)

      Jose R. Cabrero-Antonino, Antonio Leyva-Pérez and Avelino Corma

      Version of Record online: 23 FEB 2012 | DOI: 10.1002/adsc.201100731

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    4. Chymopapain-Catalyzed Direct Asymmetric Aldol Reaction (pages 712–719)

      Yan-Hong He, Hai-Hong Li, Yan-Li Chen, Yang Xue, Yi Yuan and Zhi Guan

      Version of Record online: 23 FEB 2012 | DOI: 10.1002/adsc.201100555

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    5. Hydroxyl Radical Promotes the Direct Iodination of Aromatic Compounds with Iodine in Water: A Combined Experimental and Theoretical Study (pages 720–729)

      Peng Zhang, Dongqing Sun, Mingwei Wen, Jingkui Yang, Kebin Zhou and Zhixiang Wang

      Version of Record online: 23 FEB 2012 | DOI: 10.1002/adsc.201100765

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  5. Updates

    1. Top of page
    2. Cover Picture
    3. Contents
    4. Communications
    5. Full Papers
    6. Updates
    1. Ene Reductase-Catalysed Synthesis of (R)-Profen Derivatives (pages 751–756)

      Jörg Pietruszka and Melanie Schölzel

      Version of Record online: 23 FEB 2012 | DOI: 10.1002/adsc.201100743

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